Brand name: methotrexate
Generic name: Rheumatrex, amethopterin, MTX, Methoblastin, Emthexate

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However, elderly patients are more likely to have age-related renal function impairment, which may require adjustment of dosage in patients receiving leucovorin as a rescue from the effects of high-dose methotrexate. Methotrexate elimination is reduced in patients with impaired renal function, ascites, or pleural effusions. He was treated for RA with infliximab (3 mg/kg) for 3 years, as well as methotrexate (20 mg/week), and corticosteroids. Interstitial pneumonitis has been reported in a limited number of patients receiving infliximab concomitantly with a stable dosage of methotrexate. In patients receiving concomitant methotrexate, the incidence was 6% compared to 26% with Humira monotherapy. It is recommended that duration of leucovorin administration in these patients be based on determination of plasma methotrexate concentrations. Methotrexate has been reported to cause fetal death and/or congenital anomalies. May aid in identifying patients with delayed methotrexate clearance; toxicity appears to be related at least as much to the length of time that methotrexate concentrations are elevated as to the peak concentrations achieved.

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